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Chemogenomic profiling provides insights into the limited activity of irreversible EGFR inhibitors in tumor cells expressing the T790M EGFR resistance mutation

机译：化学基因组学分析为表达T790m EGFR抗性突变的肿瘤细胞中不可逆EGFR抑制剂的有限活性提供了见解。

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Sos, M.; Rode, H.; Heynck, S.; Peifer, M.; Fischer, F.; Klüter, S.; Pawar, V.; Reuter, C.; Heuckmann, J.; Weiss, J.; Ruddigkeit, L.; Rabiller, M.; Koker, M.; Simard, J.; Getlik, M.; Yuza, Y.; Chen, T.; Greulich, H.; Thomas, R.; Rauh, D.;
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年度 2010
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1. 第一代酪氨酸激酶抑制剂治疗中发生进展的非小细胞肺癌血浆表皮生长因子受体(EGFR) T790M突变提示了失败部位并预测了临床预后:一项前瞻性观察研究 [J] . Shirong Zhang, Lucheng Zhu, Bing Xia, 癌症（英文版） . 2018 ,第009期
2. Chemogenomic profiling provides insights into the limited activity of irreversible EGFR Inhibitors in tumor cells expressing the T790M EGFR resistance mutation. [J] . Sos ML, Rode HB, Heynck Cancer research: The official organ of the American Association for Cancer Research, Inc . 2010 ,第3期

机译：化学基因组分析提供了洞悉表达T790M EGFR耐药性突变的肿瘤细胞中不可逆EGFR抑制剂有限活性的信息。
3. Antitumor activity of ASP8273, an irreversible mutant selective EGFR-TKI, in NSCLC patients with tumors harboring EGFR activating mutations and T790M resistance mutation [J] . Murakami H., Nokihara H., Shimizu T., European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) . 2014 ,第Suppla6期

机译：ASP8273（一种不可逆的突变选择性EGFR-TKI）对具有EGFR激活突变和T790M耐药性突变的NSCLC患者的抗肿瘤活性
4. Mutant-Selective Irreversible EGFR Inhibitor, Naquotinib, Inhibits Tumor Growth in NSCLC Models with EGFR-Activating Mutations, T790M Mutation, and AXL Overexpression [J] . Hiroaki Tanaka, Hideki Sakagami, Naoki Kaneko, Molecular cancer therapeutics . 2019 ,第8期

机译：突变体选择性不可逆EGFR抑制剂Naquotinib抑制NSCLC模型中的肿瘤生长，具有EGFR激活突变，T790M突变和AXL过表达
5. Detection of EGFR T790M Mutation in Circulating Tumor DNA by Using a Novel Highly Sensitive PNA-Based Method [C] . Jin Kim, Ji-Youn Han, Geon Kook Lee, International Molecular Medicine Tri-Conference. . 2015

机译：用新型高敏感的基于PCNA的方法检测循环肿瘤DNA的EGFR T790M突变
6. EGFR expression and activation in bovine cumulus cells and EGFR intramolecular regulation through interactions between tyrosines. [D] . Zhao, Zhong. 2005

机译：通过酪氨酸之间的相互作用，牛卵丘细胞中的EGFR表达和活化以及EGFR的分子内调控。
7. Frequency of EGFR T790M mutation and multimutational profiles of rebiopsy samples from non-small cell lung cancer developing acquired resistance to EGFR tyrosine kinase inhibitors in Japanese patients [O] . Ryo Ko, Hirotsugu Kenmotsu, Masakuni Serizawa, 2016

机译：来自非小细胞肺癌的EGFR T790M突变频率和多活检样本在日本患者中对EGFR酪氨酸激酶抑制剂产生了获得性耐药
8. Chemogenomic Profiling Provides Insights into the Limited Activity of Irreversible EGFR Inhibitors in Tumor Cells Expressing the T790M EGFR Resistance Mutation [O] . Sos, M., Rode, H., Heynck, S., 2010

机译：化学基因组分析提供了不可逆EGFR抑制剂在表达T790m EGFR抗性突变的肿瘤细胞中的有限活性的见解。

Chemogenomic profiling provides insights into the limited activity of irreversible EGFR inhibitors in tumor cells expressing the T790M EGFR resistance mutation

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